If we can fully map the structure of our brains, will we be able to understand how they work? That is the goal of researchers attempting to build a wiring diagram, or connectome, of our neural pathways â but now it seems uncovering the secrets of the brain may not be so simple.
You can think of the connectome as a map of all the possible roads along which neural signals can travel, but now Ěýat Princeton University and her colleagues have discovered that some of these roads are underused.
The researchers looked at the connectome of the nematode worm Caenorhabditis elegans, and compared it with a record of the wormâs neural signals, which they assembled by stimulating each neuron and tracking how the signal it emitted moved through the connectome. This is possible in the worm because its brain only has around 300 neurons in its entire nervous system.
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By treating the two datasets as mathematical networks, the team could determine whether groups of neurons that are very densely interconnected in the connectome also tend to exchange a large number of signals. They found that this isnât always the case.
Dvali says that there were some examples of overlap for high connection density and signal exchange, such as for groups of neurons responsible for how the worm eats, where the two networks matched really well, or neurons involved in how it moves backwards, which is an important manoeuvre for a worm escaping danger. In the latter case, the neurons were very connected in both networks though not in an identical way. But, more generally, there were enough discrepancies that the team says the connectome of an organism isnât enough to predict all of its behaviour.
Team member , also at Princeton University, says that the difference may be because signals between neurons donât always take the shortest path, and there are also known cases where neurons can communicate in ways beyond the âwiresâ that connect them. âWeâre used to using the connectome for guiding our research, and often itâs very helpful and informative, but in many cases thereâs so many connections that we wished we had more information,â he says.
âConnectomics data is often criticised as, âOh, you get only structure. You donât get behaviour.â And this paper is really probing that question to what degree we can [connect the two],â says at Northeastern University in Massachusetts.
Next, the researchers want to expand their study to account for how signals spread through the connectome when multiple neurons get stimulated simultaneously, and to look at more complex animals like aĚýfruit fly larva, which has the largest whole-brain connectome described to date. âWe are under a revolution right now of mapping out the brain,â says BarabĂĄsi.
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