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How nature, nurture and sheer randomness combine to make a unique you

We’re slowly beginning to unpick the complex interplay of genes, environment and experience that make you who you are – and like no one else who ever existed
Birth is only a waymarker on the road to becoming you
Kieferpix/Getty Images

How likely are you?

CHILDREN are generally fascinated by tales of how they came to be. Even young ones can often grasp the mind-boggling implication if the events of the story leading up to their existence had been any different: they wouldn’t be there to hear it.

Your you-ness is a precarious thing. Rerun the experiment of you with a different sperm and egg from the same people, and “you” would be as different from your current self, genetically, as siblings are from one another. If the egg were the same, but through some random fluctuation a different sperm won the race, you would also be distinctly different. For a start, depending on whether the sperm bore an X or a Y chromosome, you could have ended up another sex. “That’s a pretty big difference, right there,” says , a neuroscientist at Johns Hopkins University in Maryland and author of Unique: The new science of human individuality.

The potential for being a different you didn’t stop once destiny set your founding sperm and egg on their collision course, either. A lot of what makes you what you are is down to how your brain is connected. But your DNA doesn’t encode a precise wiring diagram: it is more like a rather hand-wavy recipe or set of instructions. Even genetically identical twins don’t end up with the same neuronal network. “A pool of cells in the developing brain might receive instructions that say: ‘About half of you move across the midline of the brain’, ” says Linden. “In one twin, 40 per cent of the cells might cross and in the other twin, 60 per cent.”

Then there is mutation. As cells of the developing embryo, and later fetus, multiply and DNA is duplicated, mistakes are made and inherited by the cells’ descendants. These mutations are known to contribute to autism and conditions such as schizophrenia. It is plausible they influence core personality traits too.

After birth, the question of what makes us who we are has long been characterised as “nature or nurture”, or genes versus upbringing. Today, we know it isn’t such a simple dichotomy. Most of our characteristics are shaped by both nature and nurture, intertwined in intricate ways.

After we are born, our brains are constantly reshaped by our everyday experiences, an idea known as neuroplasticity. To take the most extreme example, if children are abused or neglected, it can affect them long-term – but so can good or neutral experiences. How you use your brain changes its structure as well. Some professional musicians, for example, have a distinct bulge that can be seen with the naked eye at autopsies in a part of the brain that controls movement. “It turns out that what makes you ‘you’ is every conversation, every experience you’ve ever had,” says , a neuroscientist at Stanford University in California.

That’s before we even factor in how foreign bodies inside us influence our moods and emotions (see “Where are your boundaries?”). All these factors make your existence, your appearance, your feelings, your quirks and your foibles, vanishingly improbable. It may sound trite, but you truly are unique.

Topics: DNA / Genetics / Life / Reproduction